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4-Hydroxyacetophenone | Green Preservative Synergist | Cosmetic Grade Antioxidant | CAS [99-93-4]

4-Hydroxyacetophenone | Green Preservative Synergist | Cosmetic Grade Antioxidant | CAS [99-93-4]

Parahydroxyacetophenone is a natural active ingredient extracted from Asteraceae plants, which has both antiseptic and antioxidant functions:
Dual effects: antibacterial (G+/G-) + antioxidant (scavenging free radicals)

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P-Hydroxyacetophenone 4-Hydroxyacetophenone Cosmetic preservatives Natural antioxidants Usage of p-Hydroxyacetophenone Solutions to replace traditional preservatives CAS number of p-Hydroxyacetophenone Safe preservatives for sensitive skin Technical parameters of p-Hydroxyacetophenone Compound ratio with pentanediol

PRODUCT CATEGORY

Cosmetic Raw Materials

Product Description

Advantage

Recipe

FAQ

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Appearance	White crystalline powder
Purity	>99.0%
Melting Point	109-112°C
Solubility	Water 0.5g/100mL (25°C) Ethanol>50g/100mL
PH (1% Solution)	4.5-6.5
Recommended Dosage	0.1-0.8%

Product Uses

Additive-free cosmetics (claiming "paraben-free/MIT-free")

Sensitive skin care products

Natural organic formula

Product Advantage

1

Broad-spectrum Antibacterial

Escherichia coli inhibition rate ＞99% (0.5% addition).

2

High Temperature Stability

No decomposition at 180℃ (suitable for hot filling process).

3

Synergistic Enhancement

Compounding with 1, 2-pentanediol increases the effect by 2 times.

4

Safe And Mild

Eye irritation test score 0 points (OECD 405).

Construction Of Anti-corrosion System

Dissolution method:

Preferentially soluble in alcohol phase (ethanol/propylene glycol)

Heating to 60°C can accelerate dissolution

Classic compounding scheme:

Parahydroxyacetophenone 0.3%

1,2-pentanediol 2.0%

Caprylyl glycol 0.5%

Precautions:

Best effect in the pH range of 4-8

Avoid contact with high concentrations of iron ions

FAQ

Can it completely replace traditional preservatives?

It depends on the product type:
Water-based products: need to be compounded (recommended + pentanediol + caprylyl glycol)
Ointment products: can be used alone (0.5-0.8%)
Will it be inactivated in sunscreen products?

Light stability test shows:
Activity remains > 95% after 6 hours of UVB irradiation
It is recommended to use VE to enhance antioxidants
How to solve the problem of crystallization?

Treatment method:
① Predissolve in warm ethanol (1:3 ratio)
② Increase the alcohol content of the system to 5%
Can it be added to products that can be used by pregnant women?

Passed the teratogenicity test (OECD 414), safe dosage:
Retention type: ≤0.5%
Rinse type: ≤1.0%
How to detect the content?

HPLC detection conditions:
Chromatographic column: C18 (4.6×250mm)
Mobile phase: methanol: water = 55:45